Aripiprazole

Key Takeaways

• Aripiprazole is used to manage a variety of psychiatric and neurological conditions, and manages symptoms such as hallucinations, mood swings, and irritability. It can also reduce repetitive behaviors in autism and help manage tics in Tourette’s syndrome.
• The medication comes in several forms to suit different needs, including standard tablets, dissolvable tablets, a liquid solution, and injectable formulations. This variety allows for flexible dosing and easier administration for patients of all ages.
• Aripiprazole works by balancing dopamine and serotonin activity in the brain, which soothes overactive areas while supporting underactive ones. This helps improve mood, reduce hallucinations and agitation, and support cognitive function.

Understanding Aripiprazole

Aripiprazole is an FDA-approved medication classified as an atypical antipsychotic, or third-generation antipsychotic, and is used to treat several psychotic and mood disorders. These include schizophrenia, major depressive disorder, bipolar I (including both manic and mixed episodes), Tourette’s syndrome, and autism-related irritability. ^{[1] [2] [3]}

Additionally, the drug is available as an injectable form to manage agitation linked to schizophrenia or bipolar mania. Aripiprazole is available in several forms, including tablets, oral solutions, injections, orally disintegrating tablets, and oral films (thin strips that dissolve quickly in the mouth without requiring water). ^{[1] [2]}

Aripiprazole is also prescribed at times off-label to support treatment in individuals with substance use disorders. It may also be used to manage psychosis and agitation related to dementia, and has been used to treat delirium and certain movement-related conditions, such as difficulty opening the eyelids (which is linked to Parkinson’s disease). It is important to mention that these are less common and less established treatments, but there is evidence to support these off-label treatments in certain circumstances. ^[3]

Studies suggest that aripiprazole may reduce psychiatric hospitalizations, ease tardive dyskinesia (a condition that causes involuntary, repetitive movements - often of the face, lips, or tongue), improve cognitive function, and lower cardiovascular and hormonal risk factors. The drug has also been linked to improved sexual function and reduced cravings in alcoholics. ^[3]

How it Works

Aripiprazole is increasingly replacing older antipsychotic medications as the medication has been found to cause fewer side effects. By regulating dopamine activity, aripiprazole leads to fewer movement and metabolic problems compared to other typical and atypical antipsychotics, making it a good option for patients with severe side effects or limited treatment responses. ^[3]

In terms of how aripiprazole works to reduce psychiatric symptoms, the medicine has been shown to balance the feel-good brain chemicals known as dopamine and serotonin. In other words, aripiprazole can both boost and reduce dopamine depending on whether there is too much or too little. ^{[2] [3]}

This serves to calm overactive brain areas that cause hallucinations or agitation, while leaving normal areas mostly unaffected, which works to reduce movement-related side effects. Additionally, aripiprazole has been shown to adjust certain brain signals that serve to improve symptoms such as lack of motivation and thought-related difficulties. ^[3]

Brand Names

Aripiprazole is sold under several brand names, including: ^{[1] [4]}

• Abilify (tablets)
• Opipza (oral films)
• Mezofy (oral films)
• Abilify Maintena (monthly injection)
• Abilify Asimtufii (injection every two months)
• Aristada (injection)

How Common Is It?

In 2023, aripiprazole ranked as the 95th most commonly prescribed drug in the United States and was estimated to have been prescribed over 7 million times within that year (although this number reflects repeat scripts for more than 1.5 million patients). These figures highlight its widespread prevalence and common use in treating psychiatric conditions. ^[5]

Aripiprazole Side Effects

While not everyone who uses aripiprazole experiences side effects, a few of the more common adverse reactions include: ^[1]

• Difficulty sleeping
• Blurred vision
• Headaches
• Dizziness
• Fatigue, drowsiness, or tiredness
• Nausea, vomiting, or constipation
• Changes in appetite (increased or decreased)
• Weight gain
• Muscle stiffness or uncontrolled movements
• Shaking, restlessness, or anxiety
• Increased saliva or drooling
• Cold-like symptoms such as a blocked nose, sore throat, or sneezing

It is important to consult with your doctor should any of these symptoms present, as your prescribed dosage may require adjusting.

Dangerous and Rare Side Effects

In addition to the more common side effects of aripiprazole, in rare cases, some individuals may encounter dangerous warning signs that could lead to serious and even life-threatening health complications. For this reason, it is essential to seek urgent medical attention if you notice any of the following: ^[1]

• Seizures
• Extreme agitation, irritability, hostility, aggression, impulsivity, distress, restlessness, increased speech, or suicidal thoughts
• Mood changes, including new or exacerbated anxiety, insomnia, depression, or panic attacks
• Uncontrolled or twitching movements of the face, eyes, tongue, or limbs
• Difficulty speaking or swallowing, or a stiff, mask-like facial expression
• Severe muscle stiffness, high fever, sweating, confusion, irregular heartbeat, or faintness
• Fever, sore throat, weakness, red or purple spots beneath the skin, unusual bleeding or bruising
• Hives, difficulty breathing, or a swollen face (particularly dangerous near the throat, lips, and tongue)
• Behavioural addiction-related urges (e.g. sex, gambling, spending, etc.)
• Excessive thirst, frequent urination, dry mouth, or fruity-smelling breath

Keep in mind that this is not a comprehensive list of side effects, and it is best to exercise caution by seeking medical attention should any unusual symptoms manifest after taking aripiprazole.

Precautions, Considerations, and Risks

All medications have the potential to cause adverse reactions in certain population groups, and these differ from drug to drug based on individual chemical makeup. In terms of aripiprazole, it is important to be aware that the medicine is not approved for treating dementia-related psychosis and may increase the risk of death in older adults with this condition. ^[1]

Additionally, people with depression or other mental health disorders may experience suicidal thoughts, particularly after just starting to take aripiprazole. For this reason, it is essential to monitor your mood after beginning treatment and inform your doctor of any changes immediately. As the oral solution of aripiprazole contains sugar, those with diabetes should take other forms of the drug. ^[1]

In addition to diabetes, aripiprazole can cause high blood sugar, elevated cholesterol, and weight gain, which may increase the risk of heart disease and stroke. It is best to avoid driving or tasks that require alertness or clear vision until you know how aripiprazole affects you. Furthermore, it is essential to gradually reduce doses of the drug to avoid withdrawal symptoms when discontinuing the medication. ^[1]

Inform your healthcare provider if you are pregnant, breastfeeding, planning to become pregnant or breastfeed, or have a history of: ^[1]

• Seizures
• Allergies
• Heart problems or a history of stroke
• High or low blood pressure
• Low white blood cell count

Aripiprazole Interactions

Several medications can negatively impact how aripiprazole works or increase the risk of side effects. With this in mind, before starting to take aripiprazole, check with your doctor or pharmacist to ensure any other medicines you take are safe to use in combination with the drug. While this is not a comprehensive list, it is important to inform your healthcare provider if you are taking any of the following: ^[6]

• Antidepressants
• Heart rhythm medications
• Blood pressure pharmaceuticals
• Medicines that cause drowsiness
• Antifungal drugs
• HIV treatments
• Tuberculosis medications
• Epilepsy drugs
• Migraine pharmaceuticals

Aripiprazole Dosage

Aripiprazole is available as standard tablets ranging from 1 to 30mg, dissolvable tablets (available in doses between 10 and 30mg), liquid (where 1mg is equal to 1ml), and injections (which are typically administered monthly). Your dose depends on your condition, age, and individual response, and may be adjusted by your doctor. ^[6]

Adults with schizophrenia typically start at 10 to 15mg daily, increasing up to 30mg if needed. On the other hand, children and adolescents start at lower doses, which may be gradually increased. For the treatment of mania, adults usually start at 15mg, while children and teenagers begin with low dosages before increasing the amount as needed. ^[6]

What to Do in the Event of an Overdose

In the event of an overdose, contact the Poison Control Helpline at 1‑800‑222‑1222 or visit https://www.poisonhelp.org/help for guidance. If the person who has taken too much aripiprazole collapses, has a seizure, is struggling to breathe, or becomes unresponsive, call emergency services at 911 right away. ^[4]

Aripirazole FAQs

What should I do if I miss a dose?

If you miss a dose of aripiprazole, take it as soon as you remember. If it is nearly time for your next dose, simply skip the missed one, but do not take two doses at the same time.

How will I feel on aripiprazole?

Within days to weeks, aripiprazole may help you feel calmer, think more clearly, focus better, and relate more comfortably with others. It can also reduce hallucinations and improve memory.

Are there any activities or substances I should avoid while taking this medicine?

Avoid standing up too quickly, as this may cause dizziness, and do not drive or engage in risky activities until you know how aripiprazole affects you.

How is aripiprazole different from other antipsychotics?

Aripiprazole works like other antipsychotics but generally causes fewer side effects, making it easier to tolerate for many patients.

Will aripiprazole affect my contraception?

Aripiprazole does not interfere with contraceptives, but vomiting caused by the medication may reduce the effectiveness of birth control pills.

Can I drink alcohol while taking aripiprazole?

It is best to avoid alcohol while taking aripiprazole, as it can increase drowsiness, worsen symptoms, and reduce the medication’s effectiveness.

Does Aripiprazole Cause Weight Gain?

Aripiprazole may cause weight loss or gain, though it typically causes less weight gain than many other atypicals (often minimal or none; possible initial loss), but modest gain can occur, especially long-term or in certain populations (e.g., pediatrics). If you notice changes in your weight after beginning treatment, consult with your doctor or pharmacist. ^[6]

How Long Does Aripiprazole Take to Work?

Aripiprazole may take anywhere from a few days to several weeks before it starts to work, with full effects often only seen after 2 to 3 months. It is important to continue taking the drug even if you feel more stable to prevent symptoms from returning. ^[6]

Is Aripiprazole Addictive?

Aripiprazole is not addictive as a substance, but it can rarely trigger impulse-control problems, such as compulsive gambling, eating, shopping, or sexual behaviors. These effects often improve if the dose is reduced or the medication is stopped. ^[7]

Final Thoughts

Aripiprazole is a widely used antipsychotic that treats a range of psychiatric conditions, including schizophrenia, bipolar disorder, major depression, Tourette’s syndrome, and autism-related irritability. Its multiple formulations (tablets, dissolvable tablets, oral solution, and injections) allow for flexible dosing that accommodates different patient needs.

By regulating dopamine and serotonin activity, aripiprazole stabilizes mood, reduces hallucinations, agitation, and cognitive difficulties, and generally causes fewer side effects than other antipsychotics. Although generally well tolerated, aripiprazole requires monitoring for side effects and drug interactions, with medical supervision ensuring safe and effective treatment.

Author

Star Gorven

Star Gorven is a wellness and mental health writer with a talent for crafting evocative and evidence-based content across a wide range of topics. Her work blends analytical research with imagination and personality, offering thoughtful insights drawn from her exploration of subjects such as psychology, philosophy, spirituality, and holistic wellbeing.

Activity History - Last updated: March 19, 2026, Published date: March 19, 2026

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Reviewer

David MilesPharmD

David is a seasoned Pharmacist, natural medicines expert, medical reviewer, and pastor.

Activity History - Medically reviewed on April 2, 2026 and last checked on March 19, 2026